ABSTRACT
Age-related macular degeneration is one of the major causes of blindness in the elderly.As an important pathway of cell metabolism,autophagy maintains intracellular homeostasis through the degradation and recycle of damaged organelles and macromolecules.Understanding its mechanism may promote discoveries to delay aging process,reduce the incidence of age-related diseases.In mammals,silent information regulator protein 6 (SIRT6) plays its deacetylase and ribonucleotransferase activity in multiple signaling pathways,including inhibition of cellular senescence,tumorigenesis,metabolic diseases,regulating cellular lifespan.It has a significant impact on the structure and function of tissues and organs.SIRT6 regulates intracellular autophagy mainly through the insulin-like growth factor-protein kinase B-mammalian target of rapamycin,reducing the accumulation of toxic metabolites and cellular senescence.The function of SIRT6 in age-related macular degeneration need to be combined with the genetic background,pathogenesis,clinical manifestations and other aspects of the disease,and it is expected to be further studied in subsequent studies.